Publications
for an up-to-date list please see: http://www.ncbi.nlm.nih.gov/pubmed/?term=ryan%2C+karen+k
Chaffin A T-B^, Fang Y^, Larson KR^, Mul JD, Ryan KK*(2019) Sex-dependent effects of Mc4r genotype on HPA axis tone: implications for stress-associated cardiometabolic disease. Stress, 11: 1-10.
Larson KR^, Chaffin A T-B^, Goodson ML^, Fang Y^, Ryan KK*(2019) Fibroblast growth factor-21 controls dietary protein intake in male mice. Endocrinology, 160, 1069-1080.
Ryan KK, Packard AEB, Larson KR^, Stout J, Fourman SM, Thompson AMK, Ludwick K, Habegger KM, Stemmer K, Itoh N, Perez-Tilve D, Tschop MH, Seeley RJ, Ulrich-Lai YM (2018) Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor 21. Endocrinology, 159, 400-413.
Larson KR^, Russo KA^, Fang Y^, Mohajerani N^, Goodson ML^, Ryan KK*(2017) Sex differences in the hormonal and metabolic response to dietary protein dilution. Endocrinology, 158: 3477-3487.
Goodson ML^, Packard AEB, Buesing DR, Maney M^, Myers B, Fang Y, Basford JE, Hui DY, Ulrich-Lai YM, Herman JP, *Ryan KK (2017) Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats. Physiology and Behavior, 172: 16-23.
Thompson AK, Fourman S, Packard AEB, Egan AE, Ryan KK, Ulrich-Lai YM (2015) Metabolic consequences of chronic intermittent mild stress exposure. Physiology and Behavior, 150: 24-30.
Kohli R, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD (2015) Bile acid signaling: mechanism for bariatric surgery, cure for NASH? Digestive Diseases, 33(3): 440-446.
Myronovych A, Salazar-Gonzales R-M, Ryan KK, Miles L, Zhang W, Jha P, Wang L, Seetchell KDR, Seeley RJ, Kohli R (2014) The role of small heterodimer partner (SHP) in NAFLD improvement after vertical sleeve gastrectomy in mice. Obesity, 22(11): 2301-2311.
*Ryan KK (2014) Stress and metabolic disease. In: Weinstein M, Lane MA (eds.) Sociality, Hierarchy, Health: Comparative Biodemography. National Academies Press.
From the University of Cincinnati Lab:
Ulrich-Lai YM, *Ryan KK (2014) Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications. Cell Metabolism, 19(6): 910-925.
Ryan KK, Tremaroli V, Clemmensen C^, Kovatcheva-Datchary P, Myronovych A, Karns, R, Wilson-Perez HE, Sandoval DA, Kohli R, Backhed F, Seeley RJ (2014) FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature, 509: 183-188.
*Ryan KK, Mul JD, Clemmensen C^, Egan AE, Begg DP, Halcomb K, Seeley RJ, Herman JP, Ulrich-Lai YM (2014) Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress. Psychoneuroendocrinology, 42:98-105.
Myronovych A, Kirby M, Ryan KK, Zhang W, Jha P, Setchell KDR, Dexheimer PJ, Aronow B, Seeley RJ, Kohli R (2014) Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. Obesity, 22(2):390-400.
Clemmensen C^, Smajilovic S, Smith EP, Woods SC, Bräuner-Osborne H, Seeley RJ, D’Alessio DA, *Ryan KK (2013) Oral L-arginine elicits GLP-1 secretion to improve glucose tolerance in male mice. Endocrinology, 154(11): 3978-3983.
Ryan KK, Seeley RJ (2013) Food as a hormone. Science, 339: 918-919.
Ulrich-Lai YM, Ryan KK (2013) PPARγ and stress: implications for aging. Experimental Gerontology, 48(7): 671-676.
*Ryan KK, Kohli R, Gutierrez-Aguilar R, Gaitonde SG, Woods SC, Seeley RJ (2013) Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology, 154(1): 9-15.
Wilson-Perez HE, Chambers AP, Ryan KK, Li B, Sandoval DA, Stoffers D, Drucker DJ, Perez-Tilve D, Seeley RJ (2013) Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like peptide-1 receptor deficiency. Diabetes, 62(7): 2380-2385.
Kohli R, Setchell KDR, Kirby M, Myronovych A, Ryan KK, Ibrahim SH, Berger J, Smith K, Toure M , Woods SC, Seeley RJ (2013) A surgical model in male obese rats uncovers protective effects of bile acids post bariatric surgery. Endocrinology, 154(7):2341-2351.
*Ryan KK, Grayson BE, Jones KR, Schneider AL^, Woods SC, Seeley RJ, Herman JP, Ulrich-Lai YM (2012) Physiologic responses to acute psychological stress are reduced by the PPARγ agonist Rosiglitazone. Endocrinology, 153(3): 1279-1287.
Ryan KK, Woods SC, Seeley RJ (2012) Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metabolism, 15(2): 137-149.
Chambers AP, Wilson-Perez HE, McGrath S, Grayson BE, Ryan KK, D’Alessio DA, Woods SC, Sandoval DA, Seeley RJ (2012) The effect of vertical sleeve gastrectomy on food selection and satiation in the rat. American Journal of Physiology- Endocrinology and Metabolism, 303(8):E1076-E1084.
Sandoval DA, Ryan KK, De Kloet AD, Woods SC, Seeley RJ (2012) Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability. Nutrition and Diabetes, 2: e27.
Karen's postdoc papers:
Ryan KK, Li B, Grayson BE, Matter EK, Woods SC, Seeley RJ (2011) A role for central nervous system PPARγ in the regulation of energy balance. Nature Medicine, 17(5): 623-626.
Chambers AP, Jessen L, Ryan KK, Sisley S, Wilson-Perez HE, Stefater MA, Gaitonde S, Sorrell JE, Toure M, Berger J, D’Alessio DA, Woods SC, Seeley RJ, Sandoval DA (2011) Weight-independent changes in blood glucose homeostasis after roux-en-Y gastric bypass and vertical sleeve gastrectomy surgeries in rats. Gastroenterology, 141(3): 950-958.
Chambers AP, Stefater MA, Wilson-Perez HE, Jessen L, Sisley S, Ryan KK, Gaitonde S, Sorrell JE, Toure M, Berger JE, D'Alessio DA, Sandoval DA, Seeley RJ, Woods SC. (2011) Similar effects of roux-en-y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. Physiology and Behavior, 105 (1): 120-123.
Ryan KK, Haller AM, Sorrell JE, Woods SC, Jandacek RJ, Seeley RJ (2010) Perinatal exposure to bisphenol-A and the development of metabolic syndrome in CD-1 mice. Endocrinology, 151(6): 2603-2612.
Karen's PhD papers:
Ryan KK, Lacy RC, Margulis SW (2003) Impacts of kinship and inbreeding on components of fitness. In: Holt WV, Pickard AR, Rodger JC, Wildt DE (eds.) Reproduction and Integrated Conservation Science. Cambridge University Press.
*Ryan KK, Lacy RC (2003) Monogamous male mice bias behavior toward females according to very small differences in kinship. Animal Behavior, 65: 379-384.
*Ryan KK, Altmann J (2001) Selection for male choice based primarily on mate compatibility in the oldfield mouse, Peromyscus polionotus rhoadsi. Behavioral Ecology & Sociobiology, 50:436-440.